Adrenal Glands: Diagnostic Aspects and Surgical Therapy by Dimitrios Linos (Editor), Jon A. van Heerden (Editor)

By Dimitrios Linos (Editor), Jon A. van Heerden (Editor)

- Over two hundred beautiful illustrations, starting from intraoperative images, line drawings, diagnostic photographs, pathology slides, tables and graphs can be found to make each one case mentioned understandable and simple to follow.  - conventional and novel ther

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1 Gonadal Axis The reproductive axis is inhibited at all levels by various components of the HPA axis (Fig. 5) [72, 86, 95]. At the hypothalamic level, CRH suppresses the gonadotropin hormone releasing hormone (GnRH) neurons of the arcuate nucleus. CRH-induced b-endorphin secretion by the arcuate POMC neurons mediates this suppression, but direct inhibitory action of CRH is also suggested [25]. In addition, glucocorticoids exert inhibitory effects on the hypothalamic GnRH neuron, the pituitary gonadotroph, and the gonads themselves and render target tissues of sex steroids resistant to their actions [86].

Prog Clin Biol Res 322:119–320 3 Hypothalamic-Pituitary-Adrenal Axis 86. Rabin D, Gold PW, Margioris A, et al (1988) Stress and reproduction: Interactions between the stress and reproductive axis. In: Chrousos GP, Loriaux DL, Gold PW (eds) Mechanisms of physical and emotional stress. Plenum Press, New York, pp 377–390 87. J Clin Endocrinol Metab 71:1158–1162 88. Reichlin S (1993) Neuroendocrine-immune interactions. N Engl J Med 329:1246–1253 89. Richard D,Lin Q,Timofeeva E (2002) The corticotropinreleasing factor family of peptides and CRF receptors: Their roles in the regulation of energy balance.

Plotsky PM (1986) Opioid inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation of rats. Regul Pept 30:235–242 83. Potter E, Behan DP, Fischer WH, et al (1991) Cloning and characterization of the cDNAs for human and rat corticotropin-releasing factor-binding proteins. Nature 349:423–426 84. Proc Natl Acad Sci USA 89:4192–4196 85. Pratt WB (1990) Glucocorticoid receptor structure and the initial events in signal transduction. Prog Clin Biol Res 322:119–320 3 Hypothalamic-Pituitary-Adrenal Axis 86.

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